[vc_row][vc_column][vc_column_text]TABLE OF CONTENTS:
- What is GHK-CU
- The Study & Development
- Who Uses GHK CU Copper Peptide
- GHK CU Copper Peptide Benefits
- GHK CU Copper Peptide Side Effects
- FAQs
- Dosage
- Conclusion
Copper peptides are one of the most popular beauty trends on the planet right now!
Peptides are naturally occurring amino acids that can aid in the production of collagen and elastin, two connective tissues that keep skin smooth and firm.
Keep reading more about copper peptides’ alleged hair and skin advantages, as well as what the science says![/vc_column_text][vc_column_text el_id=”GHK-CU”]
What is GHK-CU
GHK CU Copper Peptides are part of the human body in the form of minerals that can help in making collagen and elastin, two important issues that give skin a smooth and firm appearance. GHK CU also helps the appearance of aged skin which was proven in a lot of studies. A 12-week use of a cosmetic cream with GHK-Cu to the skin of 71 women with mild to advanced skin problems such as increased skin density and thickness, reduced laxity, improved clarity, and reduced fine lines and wrinkle depth. A GHK-Cu eye lotion used around the eyes for 12 weeks to 41 women with mild to advanced problems did better than a rival vitamin K cream. It improved overall attractiveness, decreased lines and wrinkles, and boosted skin firmness and thickness.
A study also confirmed an increase in skin thickness in the epidermis and dermis, improved skin hydration, a significant smoothing of the skin by stimulating collagen synthesis, increased skin elasticity, a significant improvement in skin contrast, and increased production of collagen I in their pilot study for topical application of copper tripeptide complexes in aged skin.
GHK has been shown to have wound-healing properties in a number of animal experiments. GHK appears to stimulate wound healing via a number of methods. GHK, alone or in combination with a high-dose helium-neon laser, increased wound contraction and granular tissue creation in rabbit experimental wounds, as well as enhancing antioxidant enzyme activity and encouraging blood vessel growth. In healthy and diabetic rats, collagen dressings containing included GHK enhanced wound healing.
In wounds, the treated group had higher glutathione and ascorbic acid levels, improved epithelialization, enhanced collagen synthesis, and fibroblast and mast cell activation. PIC therapy of wounds in healthy rats enhanced collagen 9-fold. In rats, GHK-Cu increased the healing of ischemic open wounds. When compared to vehicle alone or untreated wounds, wounds healed faster.
One issue with GHK-Cu is that it is particularly susceptible to enzyme degradation. Lesion serum, such as that found on diabetic skin ulcers or bedsores, is assumed to be produced by airborne bacteria landing on the wound. [/vc_column_text][vc_column_text el_id=”Study-Development”]
The Study & Development
Since its discovery in 1973, GHK-Cu has been frequently utilized in skin and hair products. The GHK-CU Copper peptide is a tiny, naturally occurring element in the body that can be released from the body in case you’re ever in an accident.
The ability of GHK to bind copper(II) ions has been attributed to its effects by most authors. Because of its tiny size and capacity to bind copper, the GHK has been postulated to play an important role in copper metabolism. Since 2010, however, a new mechanism has begun to develop. The Connectivity Map is a publicly available library of transcriptional responses to known perturbations, or agents that modify gene expression, established by the Broad Institute of MIT and Harvard (Cambridge, MA, USA). Researchers used this approach to look into GHK’s genome-wide impacts and discovered that GHK-Cu can up- and down-regulate a large number of human genes. To establish a more comprehensive perspective of GHK’s mechanism of action, it is now possible to connect the biological effects of GHK-Cu with its effects on gene expression.
Skin repair and regeneration are aided by the formation of nerves and blood vessels. GHK and similar peptides are formed during protein breakdown after SPARC protein damage, according to Sage et al. SPARC (Secreted Protein Acidic and Rich in Cysteine) is a glycoprotein found mostly in embryonic tissues and tissues in the process of repair and remodeling. GHK and other peptides having the GHK sequence (such as KGHK), which are released from SPARC during proteolysis, stimulate the development of new vasculature in the early phases of tissue repair. GHK and GHK-related peptides limit blood vessel development later in the healing process.
The repaired area is typically devoid of sensory abilities when skin healing is poor. Both Monique Sensenbrenner’s (France) and Gertrude Lindler’s (Germany) labs discovered that GHK induces neuron outgrowth, an important aspect of skin regeneration, in cell cultures. Increased synthesis of neurotrophic factors by GHK aids in the restoration of cutaneous innervation.
Treatment of wounds with GHK results in increased levels of antioxidant enzymes, as demonstrated in animal studies. GHK also has powerful antioxidant and anti-inflammatory properties. GHK protected cultured skin keratinocytes from ultraviolet (UV) radiation by inactivating harmful free radical by-products of lipid peroxidation such as 4-hydroxynoneal, acrolein, malondialdehyde, and glyoxal. Cu(2+)-dependent oxidation of low-density lipoproteins has been demonstrated to be entirely blocked by GHK (LDL). Superoxide dismutase (SOD1), a well-known antioxidant that is also extensively used in skincare, provided just 20% protection. GHK also protects against lipid peroxidation’s harmful effects by binding by-products such acrolein and 4-hydroxynonenal.
Multiple cells must work together for successful tissue regeneration, which is regulated by cytokines and growth factors. This means that in order for regeneration to work, these molecules must be created and released in the proper quantities and locations. This is significant because no signal molecule works alone; instead, it engages in crosstalk with other signal molecules, resulting in the activation of certain cellular pathways. TGF- and integrin-regulated cellular pathways are among the mechanisms implicated in skin regeneration. GHK was then put to the test in vitro to see if it had any beneficial effects on connective tissue. GHK or TGF- were used to treat COPD lung fibroblasts that had lost their capacity to contract and remodel collagen. Fibroblast function was restored by both compounds. They also demonstrated a higher level of integrin beta 1 expression.
Topical steroids, such as cortisone, are commonly recommended for the treatment of inflammatory cutaneous conditions, although they might hinder wound healing, cause skin thinning, and cause other problems. GHK-Cu, when given systemically to mice, rats, and pigs, protects against cortisone-induced wound healing inhibition.
Fibrinogen was the single most significant risk factor for CVD risk or death, more predictive than lipoprotein cholesterol, according to the Scottish Heart Health Study, which tracked 10,359 men and women for two years. The (relative risk) increase between the highest and lowest fibrinogen levels was 301 percent for males and 342 percent for women (CVD mortality) and 259 percent for men and 220 percent for women (CVD death) (death from any cause).
The ubiquitin-proteasome system (UPS) is a system that processes and clears damaged proteins. When this system is not functioning properly, damaged proteins may start accumulating. Aging is associated with decreased activity of the ubiquitin-proteasome system. So far, there are no effective therapies to increase UPS activity. Recent work has demonstrated that proteasome activation by either genetic means or the use of compounds slows down aging. [/vc_column_text][vc_column_text el_id=”uses”]
Who Uses GHK CU Copper Peptide
Copper peptides are commonly employed by those who desire to use skincare products to improve their skin’s condition. They can also be used to treat serious skin and hair problems. Copper peptides can be found in serums and moisturizers for the face. However, peptide-based cleansers should not be used because any effects will be washed away after use.
Copper peptides are found in the most concentrated form in serum. Apply a few drops of the serum to your scalp to promote hair growth. With your fingertips, gently massage it in. It is not necessary to rinse it.
Apply your copper peptides serum to your skin in the following order for skin concerns: cleanser, toner, copper peptides serum, sunscreen (in the morning), cream, or moisturizing lotion (in the morning or afternoon, or evening), and face moisturizer.
Copper peptides are also found in several face moisturizers. Choose a cream for dry skin and a lotion for normal to oily skin for the greatest results. Use soft upward strokes twice a day, in the morning and at night.
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GHK CU Copper Peptide Benefits
Copper peptides’ components may benefit your hair and skin’s overall health in the following ways:
● Increases blood flow
According to a 2018 research review, Trusted Source, copper peptides are thought to assist enhance blood circulation in the skin. Copper has been shown to aid in the maintenance of the tissues found in blood vessels. Copper peptides may thereby activate hair follicles, allowing them to acquire enough oxygen and nutrients to develop new hair.
● Maintains hair color
Copper is one of the minerals required for melanin production. This substance is responsible for the color of your hair, as well as the color of your eyes and skin.
● Reduces the appearance of wrinkles
According to a 2015 research reviewTrusted Source, copper peptides have been found to help minimize the appearance of fine lines and wrinkles by boosting collagen proteins. Collagen may help to “plump up” your skin and reduce the look of wrinkles over time.
● Makes skin more firm
According to the same 2015 research reviewTrusted Source, copper peptides assist raise elastin proteins in addition to increased collagen formation. This may aid in the formation of tighter and smoother skin.
● Evens skin tone
Copper peptides are unique among peptides in that they have the capacity to heal your skin and level out your skin tone. Copper peptides are known to be capable of removing damaged connective tissues while simultaneously introducing new ones to your skin. This may help with sunspots (also known as age spots), acne scars, and other reasons for uneven skin tone.
● Creates antioxidant effects
Copper peptides may have antioxidant properties that help to alleviate inflammation and prevent additional damage to the skin. In addition, GHK-Cu has been shown to reduce the risk of infection.
● Other possible benefits
It’s possible that your hair development cycle has been shortened if you’re experiencing hair loss. This could be caused by problems with hair follicles, hormones, and other factors. Copper peptides have the potential to thicken existing hair strands in addition to encouraging new hair growth. This effect is supposed to be caused by increased hair follicles. More human trials are needed, however, to see if copper peptides may truly deliver these benefits.
Copper peptides have been examined for their benefits, albeit their effects on the skin have greater scientific support than their effects on hair care. Overall, further human clinical trials are needed to ensure that copper peptides are effective.[/vc_column_text][vc_column_text el_id=”Side-Effects”]
GHK CU Copper Peptide Side Effects
Certain compounds contained in other skincare treatments may lessen copper peptides’ overall efficacy.
If you see any of the following signs of an allergic response, stop using the product:
- ● Redness
- ● Hives
- ● Itching
- ● Burns
- ● Copper poisoning
Copper peptides in cosmetics do not constitute a significant concern. Peptide-containing products, on the other hand, may have certain negative effects. As a general guideline, any new skincare product should be thoroughly tested before being applied to your face or scalp. Apply a small amount of the product on the inside of your elbow and wait 24 hours to do a patch test.[/vc_column_text][vc_column_text el_id=”FAQs”]
FAQs
● When and how often should Copper peptides be used?
When you detect fine lines and wrinkles, copper peptides might be employed. What is the maximum number of times they can be used? It is also recommended to exercise twice a day, once in the morning and once in the evening.
● Is it possible to combine copper peptides with other ingredients?
Yes, other active substances that improve skin hydration and barrier function, including hyaluronic acid, amino acids, and face oils, can be coupled with copper peptides. Copper peptides, on the other hand, should not be used with direct acids, retinoids, pure or ethylated Vitamin C, or strong antioxidants.
● Copper peptides are commonly found in what form?
Copper peptides are available in serums and balms, among other forms. The efficacy of topical copper peptides in the skin, on the other hand, is determined by a variety of factors, including the formulation’s composition, the type and concentration of copper peptides used, the formula’s intended purpose, and the use of copper peptides in combination with other skincare formulas. [/vc_column_text][vc_column_text el_id=”dosage”]
Dosage
The suggested dosage for injectables is 0.2mL subcutaneously once daily. When it comes to the scalp, apply 2-3 pumps once a day at night. Finally, every night, apply 1-2 pumps to your face and massage it in. Copper peptides should not be used in conjunction with the following ingredients: retinol, vitamin C, and alpha-hydroxy acids (AHAs), such as glycolic acid.[/vc_column_text][vc_column_text el_id=”Conclusion”]
Conclusion
GHK is a low-cost, well-studied chemical that has a wide range of beneficial and health-promoting effects in a variety of tissues and systems. It’s been used in anti-aging and cosmetic goods in humans for decades with no negative side effects, and it’s simple to include into creams, liposomes, dermal patches, or microneedle delivery. If you have specific hair or skin concerns and want to incorporate copper peptides into your routine, consult a dermatologist.[/vc_column_text][vc_single_image image=”517369″ img_size=”full”][vc_column_text css=”.vc_custom_1642224166331{margin-top: -20px !important;}”]
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The information provided above is not intended to substitute professional medical advice, diagnosis, or treatment. Always seek your physician’s advice or another qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have seen or read. We bear no responsibility or liability for your use of any compound.[/vc_column_text][/vc_column][/vc_row]