Best Time To Take SARMs To Avoid Side Effects

Many people, including experienced SARMs users, will tell you there’s no best time to take SARMs; just ensure you’re imbuing them once a day.

As someone who has now been experimenting with SARMs for over eight years, I would like to put my two cents in.

Best Time To Take SARMs

I personally believe there’s a marked difference, depending on what SARM or compound related to SARMs you’re imbuing and this article is here to prove it.

SARMs Have Side Effects

This is a simple fact far too many people gloss over.

SARMs have an adverse effect on your body and mind, as much as we would like to believe otherwise.

The side effects we’re particularly concerned about are as follows:

  • Headaches
  • Nausea
  • Vision issues
  • Troubles with sleep
  • Oversleeping
  • Aggression
  • High blood pressure

The reason why we’re concerned with the above is that we can influence how these side effects will play out in our bodies.

It’s simply done by changing our time of consumption, thereby avoiding some of the more concerning side effects.

Please note that SARMs affect everyone differently; I’ve had people emailing me about Ostarine causing insomnia.

On the other hand, I’ve had a case where Ostarine caused oversleeping.

It might sound like an obvious contradiction but both are possible given two different bodies.


Just wanted to make that clear before starting with the list; you will not be able to predict your particular side effects with SARMs.

The best thing you can do is read this article in its entirety and apply the knowledge from it on your particular case.

Best Time to Take Ostarine

Ostarine is the most popular and most researched SARM till this date, making it the safest option by far.

However, many people think Ostarine can’t cause suppression and that it’s relatively side effect free, which is not entirely correct.

Ostarine can cause mild to moderate testosterone suppression and many newbies find themselves unprepared to handle it.

Possible Side Effects

  • Nausea
  • Insomnia
  • Joint pain
  • Hair shedding
  • Testosterone suppression


The best time to take Ostarine would be either before going to bed or in the morning.

If you notice that Ostarine negatively affects your sleep schedule, take it in the morning.

However, if you feel dizzy or nauseous after imbuing Ostarine, it would be best to take it at night, just before going to bed.

Other side effects can’t be avoided and happen independently of the time of consumption.

Read my full Ostarine review to get a better overview of all the benefits and side effects.

Best Time to Take Ligandrol

Ligandrol is one of the stronger SARMs out there and it can cause testosterone suppression even at lower dosages.

Ligandrol is most often used for bulking as it boosts muscle mass and strength, even helping with recovery time.

However, Ligandrol can also cause bloating, water retention and other side effects we’ll shortly name.

Possible Side Effects

  • Headaches
  • Nausea
  • Dry mouth
  • Hair shedding
  • Insomnia
  • High blood pressure


Just as with Ostarine, the best time to take Ligandrol would be either in the morning or at night.

If you’re someone prone to insomnia, take Ligandrol in the morning.

However, if you experience headaches and/or nausea, take it at night.

I highly recommend the avoidance of taking it before or after the gym, as high blood pressure is a legitimate concern.

Ensure that you’re measuring your blood pressure at least once a week while you’re on a Ligandrol cycle.

Check out my full Ligandrol review for more information.

Best Time to Take RAD140

RAD140 is a potent muscle builder and unlike Ligandrol, it doesn’t cause water retention but bestows the user with dry gains.

RAD140 works in a dose-dependent manner, meaning the more you take, the better it will work.

However, caution should be applied, as higher dosages yield more side effects.

Possible Side Effects

  • Stomach ache
  • Testosterone suppression
  • Aggression
  • Liver toxicity
  • Hair shedding
  • Nausea 
  • Headaches


The best time to take RAD140 would be either one hour before the gym or in the worst-case scenario, at night.

Let me explain.

The best option would be to just before the gym, as you want to use the aggression and dominance of RAD140 to your benefit.

However, if you get nauseous, dizzy or suffer from headaches and stomach aches, it’s best to simply take it at night.

This way, you’re effectively negating the side effects, as you’ll be fast asleep before they set in.

Read my RAD140 review for more information.

Best Time to Take Andarine

Andarine is a SARM that’s basically the failed version of Ostarine.

If I ever had to choose between the two, I would always opt for Ostarine.

Not because it necessarily procures better results but because it doesn’t have as many side effects.

Possible Side Effects

  • Sensitivity to light
  • Vision issues
  • Testosterone suppression
  • Liver damage
  • Hair shedding
  • Cardiovascular problems


To be perfectly honest, I would skip this SARM completely and opt for Ostarine instead.

If you really do want to take it for some reason, I suggest imbuing it before going to sleep.

This way, you’ll notice any vision changes or light sensitivity before you start your next day.

The only problem with this approach is that Andarine has a half-life of four hours.

You’re basically forced to take it multiple times per day

There’s no real solution to this, simply skip this SARM in favor of Ostarine.

Also, Andarine can pose a real threat to you if you do anything that requires your eyesight, which is basically everything.

To conclude, the best time to take Andarine is just before going to bed.

Take a look at my entire Andarine review for more details about this SARM.

Best Time To Take YK11

Now we’re heading into big boy territory, YK11 is a hybrid compound, considered both a SARM and steroid.

Its effects on muscle mass and strength are unprecedented, you’ll start noticing results as quickly as a week into your cycle.

With great power comes great responsibility; there are still some side effects you should know about.

Possible Side Effects

  • Increased aggression
  • Mild to moderate acne
  • Hair loss
  • Testosterone suppression
  • Joint pain
  • Nausea
  • Stomach ache
  • Headache
  • Liver damage


We’ll take a similar approach as with RAD140.

The best time to take YK11 would be one hour before the gym, as to maximize your pump with the aggression bestowed by this SARM.

Of course, if you suffer bouts of nausea or headaches and stomachaches, take it at night.

This way, you’ll avoid these pesky side effects and still be able to get a good workout in.

Do read my YK11 review before doing anything, as this is one of the most potent SARMs out there.

Best Time to Take S23

S23 is the absolute king of SARMs, outperforming all the others, even YK11, by a wide margin.

One problem with S23 is the obvious lack of human studies, making it kind of a gamble to take in the first place.

S23 has serious side effects, some of which can be avoided, others not so much.

Possible Side Effects

  • Testosterone suppression
  • Night sweats
  • Aggression
  • Hair shedding
  • Darker urine


Three things to consider when determining the best time to take S23; night sweats, dark urine and aggression.

Following this, the most logical approach would be to take it in the morning, exactly 30 to 60 minutes before going to the gym.

Reason being that you can sufficiently hydrate during the day, as to avoid dark urine and night sweats, all while ‘abusing’ the aggression of S23.

Read my entire S23 review to better acquaint yourself with this SARM.

Best Time to Take MK-677

Please note that MK-677 isn’t a SARM but a ghrelin mimetic and more importantly, a growth hormone secretagogue.

All this leads many to believe that they can achieve marvelous things with the compound, including the usage of MK-677 as PCT!

However, MK-677 is notorious for causing munchies and you have to be very careful with the side effects, as they are often unexpected.

Possible Side Effects

  • Water retention
  • Increased hunger
  • Anxiety


The best time to take MK-677 depends on two questions: are you bulking and does MK-677 cause anxiety?

If you are bulking and MK-677 isn’t causing anxiety, take it in the morning or before going to the gym.

However, if you’re cutting or at maintenance, take it at night to avoid excessive hunger.

If you experience anxiety on MK-677, try lowering your dosage.

Don’t forget to read my MK-677 review for a broader perspective.

Best Time To Take Cardarine

Once again, this compound isn’t a SARM but a PPAR-delta agonist, which basically stands for; you’ll be able to run like a horse!

Cardarine is the best endurance enhancer in the world with practically no side effects.

I highly recommend this compound to anyone who wants to lose fat and weight or simply increase his endurance and stamina.

Since Cardarine doesn’t really have any side effects, there’s nothing to avoid.

However, I still posit the best time to take Cardarine to be one hour before hitting the treadmill.

Reason being that one hour into consumption, serum concentration levels of Cardarine are at their highest.

This should lead to better results in the long term, although there haven’t been any studies confirming this notion.

Read my entire Cardarine review now and learn all the ins and outs of this compound.

Best Time To Take Stenabolic

Many people think Stenabolic is similar to Cardarine but that is not quite the case.

Stenabolic is also not a SARM but a Rev-ErbA ligand.

The latter means it affects molecules responsible for cell synthesis in the liver, muscles and fat tissues.

This leads to weight and fat loss, making Stenabolic the perfect compound for a cut.

Stenabolic only has one side effect; wakefulness, which is fully avoided by imbuing it in the morning.

There is one problem; Stenabolic’s half-life is only around 4 to 6 hours, which means you’re basically forced to take it multiple times per day.

My personal suggestion would be to ditch Stenabolic altogether and just take Cardarine.

Although these are different compounds, their effects are similar.

All in all, the best time to take Stenabolic would be in the morning, to avoid insomnia.

Read my Stenabolic review for more details!


Now that we’ve gone through the best time to take SARMs, it’s time to pick one and learn everything about it by reading!

I personally suggest avoiding Stenabolic and Andarine altogether but to each their own.

If you don’t know where to buy SARMs, make sure you visit my list of recommended companies!

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